Appendix - Biphasic Response as a Mechanism against Mutant
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APPENDIX BIPHASIC RESPONSE AS A MECHANISM AGAINST MUTANT 4 TAKEOVER IN TISSUE HOMEOSTASIS CIRCUITS ............................................................. 1 5 Appendix Section S1. Modeling the growth rate of cells in tissue homeostasis circuits. .............. 2 6 Appendix Section S2. Modeling input delay in feedback homeostasis circuits. ............................ 4 7 Appendix Section S3. Simulation of glucose dynamics and the induction of a glucokinase mutant. 8 ...................................................................................................................................................... 6 9 Appendix Section S4. Derivation of the evolutionary stability of a circuit with biphasic control. 10 .................................................................................................................................................... 10 11 Appendix Section S5. Evolutionary stability of circuits that consist of multiple compartments. . 14 12
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